Next Generation of Supplements


Found in:
Leaves and fruits of certain plants.

Do you need it?
It sure feels very good those early mornings, when the 2-o´clock dip hits or when working late. Actually, it feels good to be alert and awake when you need to.

Consequences of not getting enough
Zombie state has been observed.

Cognitive functions
Widely used for focus and attention, caffeine supports mental alertness by stimulating the central nervous system. Numerous studies have shown that caffeine is known to exert positive effects on cognitive performance such as reaction time, alertness, and sustained attention.

Two double-blind, placebo-controlled crossover studies found that moderate levels of caffeine enhanced sustained attention and alertness, decreased feelings of mental fatigue, reduced reaction time, improved performance on attention tasks and increased overall mood ratings:

Effects of a single, oral 60 mg caffeine dose on attention in healthy adult subjects. A naturalistic investigation of the effects of day-long consumption of tea, coffee and water on alertness, sleep onset and sleep quality. Many controlled trials in humans show that coffee improves various aspects of brain function. This includes memory, mood, vigilance, energy levels, reaction times and general cognitive function: The impact of caffeine on mood, cognitive function, performance and hydration: a review of benefits and risks. Effects of caffeine on mood and performance: a study of realistic consumption. The effects of low doses of caffeine on human performance and mood.

Coffee can help people feel less tired and increase energy levels: Investigation of the Effects of Coffee on Alertness and Performance during the Day and Night. A naturalistic investigation of the effects of day-long consumption of tea, coffee and water on alertness, sleep onset and sleep quality.

Several studies show that caffeine can boost the metabolic rate by 3-11%: Normal caffeine consumption: Influence on thermogenesis and daily energy expenditure in lean and potobese human volunteers. Comparison of changes in energy expenditure and body temperatures after caffeine consumption. Other studies show that caffeine can specifically increase the burning of fat, by as much as 10% in obese individuals and 29% in lean people: Metabolic effects of caffeine in humans: lipid oxidation or futile cycling?


Vitamin K2

  • Bone Support
  • Heart health
  • Muscles

Found in
Natto, hard cheeses, egg yolk.

Consequences of not getting enough
Deficiency could reduce bone mineralization and contribute to osteoporosis.

Vitamin K2 appears to increase cardiac output.
Increased risk of cardiovascular heart disease.

Do you need it?

Vitamin K2 is not typically common in a Western diet because they are found in a variety of fermented foods.  You may need Vitamin K2 if you have a disease that affects absorption in the digestive tract, such as Crohn’s disease or active celiac disease. Or if you take drugs that interfere with vitamin K absorption, if you are severely malnourished, or drink alcohol heavily.

Bone healthPost-menopausal women, who have the highest rate of osteoporosis, were selected for a 2009 clinical study on the effects of Vitamin K on bone health. 244 healthy postmenopausal women were given 180mcg per day of vitamin K2 or a placebo for three years, and their bone strength and density was measured each year. Vitamin K2 reduced age-related decline in bone mineral content and bone mineral density at the lumbar spine and femoral neck, but not at the total hip. Bone strength was affected positively by vitamin K2 and a decrease in the loss of vertebral height in the lower thoracic region was found: Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women

In a 1991 study, blood samples were taken from two groups in order to review the levels of vitamin K2. The subjects in the first group had osteoporosis and had experienced a recent fracture; those in the second group were healthy and did not have osteoporosis. Vitamin K2 levels were significantly higher in the group without osteoporosis. In the osteoporosis group, only two of the 29 patients were getting sufficient levels of vitamin K2:

Depressed levels of circulating menaquinones in patients with osteoporotic fractures of the spine and femoral neck. The benefits of supplementing K2 may be enhanced even further when combined with a vitamin D supplement, because the two vitamins have synergistic effects: Vitamins D and K as pleiotropic nutrients: clinical importance to the skeletal and cardiovascular systems and preliminary evidence for synergy


Vitamin K2 supplementation may boost the output of the heart by 12% in aerobically trained males and female athletes. The study’s finding might translate into an effect on edurance exercise capacity: Oral Consumption of Vitamin K2 for 8 Weeks Associated With Increased Maximal Cardiac Output During Exercise

Heart Health

Vitamin K2 supports heart health by stimulating Gla-protein in order to prevent calcification of the arteries and soft-tissue. Clinical studies have attempted to further prove the benefits of vitamin K2 for heart health. 16,057 women who were free of cardiovascular disease were analyzed using a food frequency questionnaire. After approximately 8 years there were 480 cases of cardiovascular heart disease (CHD) in the group. The average daily vitamin K2 intake for the patients who developed CHD was 29.1mcg, far below the recommended daily intake of 80mcg/day: A high menaquinone intake reduces the incidence of coronary heart disease

A 2004 study also reviewed vitamin K2 intake and its relation to CHD. The Rotterdam study reviewed the dietary intake of 4,807 subjects. They found the relative risk of CHD mortality and severe aortic calcification was reduced in the middle and upper tiers of vitamin K2 consumption when compared to the lower tier: Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study

A 2015 clinical study attempted to prove a link between vitamin K2 and arterial stiffness. 244 healthy post-menopausal women were randomized and given either a placebo or 180mcg of vitamin K2 per day. After three years, the group receiving vitamin K2 showed fewer signs of arterial stiffness than the placebo group when measured using echotracking: Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial


About US

Plein provides a monthly subscription of innovative food supplements. We also do one-time-purchases, but subscriptions are the better deal. With a one-time-purchase you will receive 1 month supply: Immune System – 5 cassettes Bone Support – 3 cassettes Caffeine – 4 cassettes With subscription you will receive 2 months supply every 2 months: Immune System – 10 cassettes Bone Support – 6 cassettes Caffeine – 8 cassettes Caffeine – whenever you need a fast-acting boost; before a job interview, in a race, during a show and on other occasions when you don’t want to spill and / or run to the bathroom. For Immune System and Bone Support follow instructions on our packaging, and adjust according to diet. Keep one cassette of each at home, in your purse, pocket, car, gym bag and at work. Use whenever it is convenient.


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